Anti-Yo Antibodies in Children With Specific Learning Disorder
DOI:
https://doi.org/10.66288/actamedi.2026.93Keywords:
Specific learning disorder, Dyslexia, Anti-Yo, Cerebellum, Purkinje cellAbstract
There is an increasing interest in immunological mechanisms in psychiatric disorders. The aim of this study is to determine the role of anti-Yo antibody in the etiology of SLD and to shed light on the immunological mechanisms that may be effective in the development of specific learning disorder. In specific learning disorder (SLD) is thought cerebellar functional and structural anomalies. Anti-Yo antibodies are immunoglobulin G (Ig G) which causes paraneoplastic cerebellar dejeneration with Purkinje cell death. The presence/absence of antibodies was tested by indirect immunofluorescence assay on 32 children with SLD and 35 healthy children. Anti-Yo antibody positivity was not detected in any of the children with SLD participating in the study. In our study, no association was found between the disease and anti-Yo antibody in children with SLD. However, since there is not a sufficient number of studies in SLD, it is not possible to say whether serum antibodies have a pathogenic role in this disease. Further studies are needed to clarify the immunological factors in the etiology of SLD.
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